PBB geneid 4145 Megakaryocyte associated tyrosine protein kinase is an enzyme that in humans is encoded by the MATK gene . ref name pmid8288563 cite journal author Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H title Identification and characterization of a novel tyrosine kinase from megakaryocytes journal J Biol Chem volume 269 issue 2 pages 1068 74 year 1994 month Feb pmid 8288563 pmc doi ref ref name pmid7530249 cite journal author Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H title Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product journal J Biol Chem volume 270 issue 4 pages 1833 42 year 1995 month Feb pmid 7530249 pmc doi 10.1074 jbc.270.4.1833 ref ref name entrez cite web title Entrez Gene MATK megakaryocyte associated tyrosine kinase url http www.ncbi.nlm.nih.gov ... to Csk tyrosine kinase and has the structural features of the CSK subfamily SRC homology SH2 .... ref name entrez Interactions Megakaryocyte associated tyrosine kinase has been shown to Protein ... The MATK tyrosine kinase interacts in a specific and SH2 dependent manner with c Kit journal J ... M, Nada S, Yamanashi Y, et al. title CSK a protein tyrosine kinase involved in regulation of src ... The MATK tyrosine kinase interacts in a specific and SH2 dependent manner with c Kit. journal J ... tyrosine kinase gene, HYL. journal Oncogene volume 9 issue 11 pages 3371 4 year 1994 pmid 7936664 ... J, et al. title Molecular cloning of a novel non receptor tyrosine kinase, HYL hematopoietic consensus tyrosine lacking kinase . journal Oncogene volume 9 issue 4 pages 1155 61 year 1994 pmid ... activity of CD36 anchored Lyn tyrosine kinase in thrombin stimulated platelets. journal EMBO J ..., Chk, binds tyrosine phosphorylated paxillin in human blastic T cells. journal Biochem. Biophys. Res ... PDB Gallery geneid 4145 Tyrosine kinases The PBB Controls template provides controls for Protein Box ... more details
OrganicBox complete wiki name Tyrosine name S 2 Amino 3 4 hydroxy phenyl propanoic acid GENERAL INFORMATION C 9 H 11 N 1 O 3 mass 181.19 abbreviation Y, Tyr image Image L tyrosine skeletal.png 150px Image L tyrosine 3D sticks.png 140px synonyms DATABASES SMILES Oc1ccc CC N C O O cc1 InChI 1 C9H11NO3 c10 8 9 12 13 5 6 1 3 7 11 4 2 6 h1 4,8,11H,5,10H2, H,12,13 f h12H CAS 60 18 4 DrugBank EINECS br 200 460 4 ref 1 a PubChem 71098 D ref 2 a , 1153 L ref 3 a PHYSICAL PROPERTIES Structure index of refraction abbe number dielectric constant magnetic susceptibility dipole moment U V data lambda max extinction coefficient Infrared data absorption bands NMR data proton NMR carbon NMR other NMR Spectrometry data mass spectrometry Phase behaviour delta fus H o delta fus S o delta vap H o delta vap S o triple point K triple point C triple point Pa criticle point K criticle point C criticle point Pa Solid properties delta f H o solid S o solid heat capacity solid density solid 1.456 melting point C 343 melting point F melting point K Liquid properties delta f H o liquid S o liquid heat capacity liquid density liquid viscosity liquid boiling point C boiling point F boiling point K Gas properties delta f H o gas S o gas heat capacity gas viscosity gas HAZARD PROPERTIES MSDS main hazards nfpa health nfpa flammability nfpa reactivity nfpa special flash point r phrases s phrases RTECS number CHEMICAL PROPERTIES XLogP 1.87 isoelectric point 5.66 disociation constant 2.24, 9.04, 10.10 tautomers 2 H bond donor 3 H bond acceptor 4 PHARMACOLOGICAL PROPERTIES References refbegin note 1 a EINECS 200 460 4 EINECS for Tyrosine note 2 a PubChem 71098 note 3 a PubChem 1153 refend AminoAcids Category Chemical data pages ar ... more details
PBB geneid 7297 Non receptor tyrosine protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 ... Favera R title Identification and chromosomal mapping of new human tyrosine kinase genes journal Oncogene ... mapping of new human tyrosine kinase genes journal Oncogene volume 5 issue 3 pages 277 ... tyrosine kinase 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... and Interleukin 12 IL 12 signaling. Function This gene encodes a member of the tyrosine kinase and, to be more ..., JAK3 and tyrosine kinase 2 TYK2 . ref name pmid9759489 cite journal author Stark GR, Kerr IM, Williams ... M, Stark GR, Pellegrini S title A protein tyrosine kinase in the interferon alpha beta signaling pathway ... with tyrosine kinases Jaks 1 2, and Tyk2 kinase . ref name pmid12171785 cite journal author ... J, Planchon SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, Larner AC title Tyk2 tyrosine kinase ... S, Miyawaki T, Nonoyama S, Karasuyama H title Human tyrosine kinase 2 deficiency reveals its requisite ... cite journal author Minegishi Y, Karasuyama H title Hyperimmunoglobulin E syndrome and tyrosine ... 2007 month December pmid 17989526 doi 10.1097 ACI.0b013e3282f1baea url issn ref Interactions Tyrosine ... H, Yi T, Platanias L C year 1995 month Aug. title Association of the interferon dependent tyrosine ... class of non receptor tyrosine kinase genes. journal Oncogene volume 5 issue 9 pages 1329 36 year ... tyrosine kinases expressed in K 562 human leukemia cells. journal Proc. Natl. Acad. Sci. U.S.A. volume ... author Colamonici O, Yan H, Domanski P, et al. title Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. journal Mol. Cell ... P, Yan H, Witte MM, et al. title Homodimerization and intermolecular tyrosine phosphorylation of the Tyk 2 tyrosine kinase. journal FEBS Lett. volume 374 issue 3 pages 317 22 year 1995 pmid 7589562 ... Association of the interferon dependent tyrosine kinase Tyk 2 with the hematopoietic cell phosphatase ... more details
protein Name ROR1 receptor tyrosine kinase like orphan receptor 1 caption image width HGNCid 10256 Symbol ROR1 AltSymbols NTRKR1 EntrezGene 4919 OMIM 602336 RefSeq NM 005012 UniProt Q01973 PDB ECnumber 2.7.10.1 Chromosome 1 Arm p Band 32 LocusSupplementaryData p31 protein Name ROR2 receptor tyrosine kinase like orphan receptor 2 caption image width HGNCid 10257 Symbol ROR2 AltSymbols NTRKR2, BDB, BDB1 EntrezGene 4920 OMIM 602337 RefSeq NM 004560 UniProt Q01974 PDB ECnumber Chromosome 9 Arm q Band 22 LocusSupplementaryData In the field of molecular biology , receptor tyrosine kinase like orphan receptors RORs are a family of tyrosine kinase receptor s that are important in regulating skeletal and neuronal development, cell migration and Cell migration Cell polarity cell polarity . ROR proteins can can modulate Wnt signaling pathway Wnt signaling by sequestering Wnt signaling pathway Ligands which act on Wnt signaling Wnt ligand s. ref name pmid18848778 cite journal author Green JL, Kuntz SG, Sternberg PW title Ror receptor tyrosine kinases orphans no more journal Trends Cell Biol. volume 18 issue 11 pages 536 44 year 2008 month November pmid 18848778 doi 10.1016 j.tcb.2008.08.006 url issn ref References Reflist protein stub Tyrosine kinases Category EC 2.7.10 ... more details
An immunoreceptor tyrosine based activation motif ITAM in the antagonistic case immunoreceptor tyrosine based inhibitory motif ITIM , I for inhibition is a conserved sequence of four amino acid s that is repeated twice in the cytoplasmic tails of certain cell surface proteins of the immune system . ref name basic citation last1 Abbas first1 Abul K last2 Lichtman first2 Andrew H. title Basic Immunology Functions and Disorders of the Immune System year 2009 publisher Saunders edition 3 place Philadelphia, PA isbn 978 1 4160 4688 2 ref Structure The motif contains a tyrosine separated from a leucine or isoleucine by any two other amino acid s, giving the signature YxxL. ref name basic Two of these signatures are typically separated by between 7 and 12 amino acids in the tail of the molecule YxxLx sub 7 12 sub YxxL . Function Image TCRComplex.png thumb The T cell receptor complex with TCR and TCR chains, CD3 receptor CD3 and chain accessory molecules. ITAMs are represented in blue on the tails of the CD3 subunits. ITAMs are important for signal transduction in immune cells. Hence, they are found in the tails of important cell signaling molecules such as the CD3 receptor CD3 and chain s of the T cell receptor complex, ref name basic the CD79 alpha and beta chains of the B cell receptor complex, and certain Fc receptor s. The tyrosine residues within these motifs become phosphorylated following interaction of the receptor molecules with their ligand s and form docking sites for other proteins involved in the cell signaling signaling pathways of the cell. References reflist DEFAULTSORT Immunoreceptor Tyrosine Based Activation Motif Category Cell signaling Category Immune system Protein stub Immunology stub ... more details
context date June 2009 The term Kinase tyrosine based inhibitory motif KTIM was coined by a group of researchers from McGill University , Montreal , Canada ref name avix Abu Dayyeh I. et al.,2008. PLoS Negl Trop Dis 2 12 e305. doi 10.1371 journal.pntd.0000305 ref in 2008 to represent any ITIM like Sequence motif motif with the consensus sequence I V L SxYxxL V found in a kinase and that regulates its activity. Introduction One major way in which cells respond to stimuli is through signal transduction pathways whereby a ligand binds to a receptor causing conformational changes that lead to a cascade of events in intracellular signalling molecules that ultimately ends up in the translocation of transcription factors to the nucleus altering the expression of target genes, therefore affecting specific cellular functions. One way activation signals can be counteracted is through the triggering of different receptors bearing immunoreceptor tyrosine based inhibitory motifs ITIMs in their cytoplasmic tails. Several transmembrane receptor s are negatively regulated through recruiting cytosolic SH2 domain containing protein s such as SHP 1 to immunoreceptor tyrosine based inhibitory motif s ITIMs that they possess. Interestingly, ITIM like motifs KTIMs were shown to exist in non receptor proteins and to play a key role in their regulation. Difference between KTIM and ITIM The main difference between ITIM and KTIM is that KTIM was shown to be found in a cytosolic protein IL 1 receptor associated Kinase 1 IRAK 1 and not in a transmembrane protein such as the case with ITIMs. ref name avix KTIM function KTIMs are speculated to play a regulatory role in the negative regulation of many kinases in addition to IRAK 1, and can thus represent a novel regulatory mechanism in a wide range of cellular kinases ref name avix ref Abu Dayyeh I. et al.,2010. Dev. Comp. Immunol.,34 5 481 484, doi 10.1016 j.dci.2009.12.012 ref . The mode of action of KTIMs is similar to ITIMs and involves recruiting ... more details
An immunoreceptor tyrosine based inhibition motif ITIM , is a conserved sequence of amino acid s S I V LxYxxI V L that is found in the cytoplasm ic tails of many inhibitory immune receptor receptors of the immune system . After ITIM possessing inhibitory receptors interact with their ligand, their ITIM motif becomes phosphorylation phosphorylated by enzyme s of the Src gene Src family kinases Src kinase s, allowing them to recruit other enzymes such as the phosphotyrosine phosphatase s SHP 1 and SHP 2 , or the inositol phosphatase called SHIP. These phosphatases decrease the activation of molecules involved in cell signaling. ref cite journal author Barrow A, Trowsdale J title You say ITAM and I say ITIM, let s call the whole thing off the ambiguity of immunoreceptor signaling journal Eur J Immunol volume 36 issue 7 pages 1646 53 year 2006 pmid 16783855 doi 10.1002 eji.200636195 ref A list of human candidate ITIM containing proteins has been generated by proteome wide scans. ref cite journal author Staub E, Rosenthal A, Hinzmann B title Systematic identification of immunoreceptor tyrosine based inhibitory motifs in the human proteome journal Cell Signal volume 16 issue 4 pages 435 456 year 2004 pmid 14709333 ref References reflist Category Immune system protein stub immunology stub sr Imunoreceptorski tirozin bazirani inhibitorni motiv ... more details
Wikify date March 2012 Soluble fms like tyrosine kinase 1 sFlt 1 or sVEGFR 1 is a tyrosine kinase protein that disables proteins that cause blood vessel growth. Soluble Flt 1 sFlt 1 is a splice variant of VEGF receptor 1 Flt 1 which is produced by a variety of tissues. sup 1 sup These proteins act as a receptor of vascular endothelial growth factor VEGF , a potent angiogenic growth factor. Another VEGF receptor is KDR . sFlt 1 soluble fms like tyrosine kinase 1 also known as VEGF receptor 1 binds and reduces free circulating levels of the proangiogenic factors VEGF vascular endothelial growth factor and PlGF placental growth factor . sFlt 1 thereby blunts the beneficial effects of these proangiogenic factors on maternal endothelium, with consequent maternal hypertension and proteinuria. Serum levels of PlGF and sFlt 1 are altered in women with preeclampsia . Moreover, circulating levels of PlGF and sFlt 1 can discriminate between a normal pregnancy and that with preeclampsia even prior to clinical presentation, and sFlt 1 and PlGF are associated with disease severity and the onset of symptoms. sup 2 sup In normal pregnancy, the pro angiogenic factor PlGF increases during the first two trimesters and decreases as pregnancy progresses to term. In contrast, levels of the anti angiogenic factor sFlt 1 remain stable during the early and middle stages of gestation and increase steadily until term. In women who develop preeclampsia, sFlt 1 levels have been found to be higher and PlGF levels have been found to be lower than in normal pregnancy. sup 3,4,5,6. sup br br In uncomplicated pregnancies, blood pressure changes from mid to late pregnancy, in particular for diastolic blood ... 3. Maynard SE, et al. Excess placental soluble fms like tyrosine kinase 1 sFlt1 may contribute to endothelial ... 741. br 8. Thadhani R, et al. First Trimester Placental Growth Factor and Soluble Fms Like Tyrosine ... Reference Values for Both Total Soluble Fms Like Tyrosine Kinase 1 and Free Placental Growth ... more details
Bcr Abl tyrosine kinase inhibitor s TKI are the first line therapy for most patients with chronic myelogenous leukemia CML . In more than 90 cases CML is caused by chromosomal abnormality resulting in the formation of a so called Philadelphia chromosome . This abnormality was discovered by Janet Rowley in 1972 and is due to fusion between Abelson Abl gene Abl tyrosine kinase gene at chromosome 9 and break ... and a constitutively active Bcr Abl tyrosine kinase that has been implicated in the pathogenesis of CML. Compounds have been developed that selectively inhibit this tyrosine kinase. Before the U.S. ... that could inhibit the Bcr Abl tyrosine kinase. This led to the discovery of second generation drugs ... Abl tyrosine kinase. ref name Buchanan2003 First generation Bcr Abl tyrosine kinase inhibitors Imatinib ... drug since it is the first Bcr Abl tyrosine kinase inhibitor to be used in the treatment of CML ... In the development of imatinib, the chemical structure structure of Bcr Abl tyrosine kinase ... for the pathogenic Bcr Abl tyrosine kinase is duplicated in the DNA sequence , leading to higher expression ... Abl protein and disrupt the binding site of imatinib on the tyrosine kinase, resulting in a loss ... fold more potent than imatinib in inhibiting activity of the Bcr Abl tyrosine kinase and Cell growth ... ref name Breccia2010 The drug effectively inhibits the auto phosphorylation of Bcr Abl on Tyrosine ... thought. Bosutinib inhibits Src, Abl and a wide range of both tyrosine and serine threonine kinases ... Druker, B. J. and Lydon, N. B. 2000 . Lessons learned from the development of an Abl tyrosine ..., P., Meyer, T. and Zimmermann, J. 2002 . Imatinib a selective tyrosine kinase inhibitor . European ..., D. and Ullrich, A. 2002 . Smart drugs Tyrosine kinase inhibitors in cancer therapy . Cancer Cell 117 123. ref ref name bixby2009 Bixby, D., Talpaz, M. 2009 . Mechanisms of resistance to tyrosine ... j.ejphar.2009.06.065 ref Category Leukemia Category Medical treatments Category Non receptor tyrosine ... more details
Morefootnotes article date March 2011 The Flt3l is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cell s in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady state pDC and cDC development. ref cite journal last1 Shortman first1 Ken last2 Naik first2 Shalin H. title Steady state and inflammatory dendritic cell development journal Nature Reviews Immunology volume 7 issue 1 pages 19 30 year 2006 pmid 17170756 doi 10.1038 nri1996 ref A lack of FLT3L results in low levels of DCs. References reflist Further reading cite journal last1 Robinson first1 S N last2 Chavez first2 J M last3 Pisarev first3 V M last4 Mosley first4 R L last5 Rosenthal first5 G J last6 Blonder first6 J M last7 Talmadge first7 J E title Delivery of Flt3 ligand Flt3L using a poloxamer based formulation increases biological activity in mice journal Bone Marrow Transplantation volume 31 issue 5 pages 361 9 year 2003 pmid 12634727 doi 10.1038 sj.bmt.1703816 Category Enzymes enzyme stub ... more details
Dual specificity phosphatase is a form of phosphatase that can act upon tyrosine or serine threonine residues. ref MeshName Dual Specificity Phosphatases ref References reflist Intracellular signaling peptides and proteins Protein tyrosine phosphatases Category Enzymes biochem stub ... more details
LTK may refer to the LTK Commune Leukocyte receptor tyrosine kinase , in biochemistry, a member of the receptor tyrosine kinase family of cell surface receptors Licence to Kill , 1989 James Bond film Little Kimble railway station , England National Rail station code LTK disambig it LTK ... more details
Orphan date January 2012 infobox biodatabase title BYKdb logo File Database.png description the Bacteria l protein Tyrosine kinase tYrosine Kinase database. scope organism center Universit Claude Bernard Lyon 1 laboratory author Fanny Jadeau pmid Jadeau & al. 2012 ref name pmid22080550 released 2011 standard format url http bykdb.ibcp.fr download webservice sql sparql webapp standalone license versioning frequency curation bookmark version The Bacterial protein tyrosine kinase database BYKdb is a specialized database of computer annotated bacterial Tyrosine kinase tyrosine kinases that share no resemblance with their eukaryotic counterparts ref name pmid22080550 cite journal quotes yes last Jadeau first Fanny authorlink coauthors Grangeasse Christophe, Shi Lei, Mijakovic Ivan, Del age Gilbert, Combet Christophe year 2012 month Jan title BYKdb the Bacterial protein tYrosine Kinase database journal Nucleic Acids Res. volume 40 issue Database issue pages D321 4 publisher location England issn pmid 22080550 doi 10.1093 nar gkr915 bibcode oclc id url pmc 3245071 language eng format accessdate laysummary laysource laydate quote ref See also Tyrosine kinase tyrosine kinases References references External links http bykdb.ibcp.fr Category Biological databases Category Protein kinases Biodatabase stub ... more details
RTK class III is a class of receptor tyrosine kinase s. It includes C KIT , C FMS , and FLT3 . ref name pmid12580961 cite journal author Abu Duhier FM, Goodeve AC, Care RS, et al. title Mutational analysis of class III receptor tyrosine kinases C KIT, C FMS, FLT3 in idiopathic myelofibrosis journal Br. J. Haematol. volume 120 issue 3 pages 464 70 year 2003 month February pmid 12580961 doi 10.1046 j.1365 2141.2003.04108.x url ref References reflist Tyrosine kinases Category Tyrosine kinase receptors ... more details
protein Name TIE1 tyrosine kinase with immunoglobulin like and EGF like domains 1 caption image width HGNCid 11809 Symbol TIE1 AltSymbols TIE, JTK14 EntrezGene 7075 OMIM 600222 RefSeq NM 005424 UniProt P35590 PDB ECnumber 2.7.1.112 Chromosome 1 Arm p Band 34 LocusSupplementaryData p33 protein Name TEK tyrosine kinase TEK tyrosine kinase, endothelial caption image width HGNCid 11724 Symbol TEK tyrosine kinase TEK AltSymbols TIE2, TIE 2, VMCM1, CD202b EntrezGene 7010 OMIM 600221 RefSeq NM 000459 UniProt Q02763 PDB ECnumber Chromosome 9 Arm p Band 21 LocusSupplementaryData The angiopoietin receptors are receptors that bind angiopoietin . TIE 1 and TEK tyrosine kinase TIE 2 comprise the cell surface receptors that bind and are activated by the angiopoietins , Ang1, Ang2, Ang3, Ang4 . The angiopoietins are protein growth factors required for the formation of blood vessels angiogenesis . Angiopoietins The angiopoietins are protein growth factors that promote angiogenesis , the formation of blood vessels. There are now four identified angiopoietins Ang1, Ang2, Ang3, Ang4. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie 1 and Tie 2. These are receptor tyrosine kinases , so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling . It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie 2 is capable of physiologic activation as a result of binding the angiopoietins. External links MeshName TIE Receptor Tyrosine Kinases Tyrosine kinases Category Tyrosine kinase receptors Category Proteins Category Developmental neuroscience ... more details
PTK may refer to IEEE 802.11i 2004 Pairwise Transient Key Phi Theta Kappa Phototherapeutic keratectomy PTK Toolkit Post and Telecom of Kosovo Protein Tyrosine Kinase Portal Three Kingdoms , a Magic The Gathering set disambig it PTK ja PTK ... more details
unreferenced date June 2010 Infobox Disease Name PAGENAME Image L tyrosine skeletal.png Caption Tyrosine DiseasesDB 29836 DiseasesDB mult ICD10 ICD10 E 70 2 e 70 ICD9 ICD9 270.2 ICDO OMIM 276710 OMIM mult MedlinePlus eMedicineSubj ped eMedicineTopic 2339 MeshID D020176 Type III tyrosinemia is a rare disorder caused by a deficiency of the enzyme 4 hydroxyphenylpyruvate dioxygenase EC number 1.13.11.27 , encoded by the gene HPD . This enzyme is abundant in the liver, and smaller amounts are found in the kidneys. It is one of a series of enzymes needed to break down tyrosine. Specifically, 4 hydroxyphenylpyruvate dioxygenase converts a tyrosine byproduct called 4 hydroxyphenylpyruvate to homogentisic acid . Characteristic features of type III tyrosinemia include mild mental retardation , seizure s, and periodic loss of balance and coordination intermittent ataxia . Type III tyrosinemia is very rare only a few cases have been reported. Amino acid metabolic pathology Category Amino acid metabolism disorders Category Autosomal recessive disorders Category Article Feedback 5 es Tirosinemia tipo 3 ... more details
Image L phenylalanine skeletal.png thumb phenylalanine Image L tryptophan skeletal.png thumb tryptophan Image L tyrosine skeletal.png thumb tyrosine Image Histidin Histidine.svg thumb histidine Image Thyroxine 2D skeletal.png thumb thyroxine Aromatic amino acids are amino acids that include an Aromaticity aromatic ring. Examples include Among 20 standard amino acids phenylalanine , tryptophan , histidine and tyrosine Others thyroxine See also Aromatic L amino acid decarboxylase Phenylalanine , histidine , and tryptophan are essential amino acids for animals. Since they are not synthesized in the human body, they must be derived from the diet. Tyrosine is semi essential it can be synthesized, but only from phenylalanine. A lack of the enzyme phenylalanine hydroxylase used in tyrosine synthesis causes phenylketonuria . All plants and micro organisms must synthesize their aromatic amino acids in order to make proteins, unlike animals which obtain them through their diet. Because of the energy intensive nature of amino acid biosynthesis, animals have lost these costly metabolic pathways, since they can obtain aromatic amino acids by ingesting other organisms. Herbicides and antibiotics take advantage of this by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro organisms but not animals. External links MeshName Aromatic Amino Acids MetabolismMap Category Amino acids Category Aromatic amino acids biochemistry stub zh ... more details
enzyme Name diiodotyrosine transaminase EC number 2.6.1.24 CAS number 9033 18 5 IUBMB EC number 2 6 1 24 GO code 0047861 image width caption In enzymology , a diiodotyrosine transaminase EC number 2.6.1.24 is an enzyme that catalysis catalyzes the chemical reaction 3,5 diiodo L tyrosine 2 oxoglutarate math rightleftharpoons math 4 hydroxy 3,5 diiodophenylpyruvate L glutamate Thus, the two substrate biochemistry substrates of this enzyme are 3,5 diiodo L tyrosine and 2 oxoglutarate , whereas its two product chemistry products are 4 hydroxy 3,5 diiodophenylpyruvate and L glutamate . This enzyme belongs to the family of transferase s, specifically the transaminases , which transfer nitrogenous groups. The systematic name of this enzyme class is 3,5 diiodo L tyrosine 2 oxoglutarate aminotransferase . Other names in common use include diiodotyrosine aminotransferase , halogenated tyrosine aminotransferase , and halogenated tyrosine transaminase . It employs one cofactor biochemistry cofactor , pyridoxal phosphate . References reflist 1 cite journal author Nakano M year 1967 title Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria journal J. Biol. Chem. volume 242 pages 73&ndash 81 pmid 4381052 issue 1 cite journal author Nakano M and Danowski TS year 1964 title Thyroid hormone transaminase and oxidase in rat kidney mitochondria journal Biochim. Biophys. Acta volume 85 pages 18&ndash 28 pmid 14159298 Transaminases Thyroid hormone metabolism enzymes and transporters Category EC 2.6.1 Category Pyridoxal phosphate enzymes Category Enzymes of unknown structure transferase stub ja ... more details
protein Name tyrosine kinase with immunoglobulin like and EGF like domains 1 caption image width HGNCid 11809 Symbol TIE1 AltSymbols TIE, JTK14 EntrezGene 7075 OMIM 600222 RefSeq NM 005424 UniProt P35590 PDB ECnumber 2.7.1.112 Chromosome 1 Arm p Band 34 LocusSupplementaryData p33 Tyrosine kinase with immunoglobulin like and EGF like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene . ref name pmid1312667 cite journal author Partanen J, Armstrong E, M kel TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K title A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains journal Mol. Cell. Biol. volume 12 issue 4 pages 1698 707 year 1992 month April pmid 1312667 pmc 369613 doi url http mcb.asm.org cgi content abstract 12 4 1698 ref Function TIE1 is a cell surface protein expressed exclusively in endothelium endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells . ref cite journal pmid 8570217 ref TIE1 upregulates the cell adhesion molecule s CAMs VCAM 1 , E selectin , and ICAM 1 through a p38 mitogen activated protein kinases p38 dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis . ref name pmid18448073 cite journal author Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP title Receptor tyrosine kinase Tie 1 overexpression in endothelial cells upregulates adhesion molecules journal Biochem. Biophys. Res. Commun. volume 371 issue 3 pages 475 9 year 2008 month July pmid 18448073 doi 10.1016 j.bbrc.2008.04.091 url ref References Reflist External links MeshName Receptor, TIE 1 Tyrosine kinases Category Tyrosine kinase receptors Category Proteins ... more details
L system may refer to L system or Lindenmayer systems in biology L carrier AT&T Transcontinental Cable System Taito L System arcade system board An alternative name for Chicago L mass transit system The main system of transport for tyrosine across biological cell membranes and the Blood brain barrier Blood Brain Barrier . disambig ... more details
LCK may refer to The IATA airport code for Rickenbacker International Airport The Lymphocyte specific protein tyrosine kinase Lck also called p56 LCK A shortened form of the word Luck used in many Role playing games Lockwood railway station , England National Rail station code LCK. Zompist.com s Language Construction Kit disambig de LCK it LCK ... more details
FGR may refer to Fetal Growth Restriction In nuclear and particle physics, Fermi s golden rule FGR gene , a human gene encoding a protein tyrosine kinase Fighter ground attack reconnaissance in British military aircraft designation systems , e.g. Eurofighter Typhoon variants Typhoon FGR4 Typhoon FGR4 Forest Green Rovers F.C. disambig it FGR ... more details
enzyme Name protein tyrosine sulfotransferase EC number 2.8.2.20 CAS number 87588 33 8 IUBMB EC number 2 8 2 20 GO code 0008476 image width caption Tyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation . ref name pmid6577005 cite journal author Lee RW, Huttner WB title Tyrosine O sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase journal J. Biol. Chem. volume 258 issue 18 pages 11326 34 year 1983 month September pmid 6577005 doi url issn ref Examples Human genes that encode protein tyrosine sulfotransferase enzymes include protein Name tyrosylprotein sulfotransferase 1 caption image width HGNCid 12020 Symbol TPST1 AltSymbols EntrezGene 8460 OMIM 603125 RefSeq NM 003596 UniProt O60507 PDB ECnumber 2.8.2.20 Chromosome 7 Arm q Band 11.21 LocusSupplementaryData protein Name tyrosylprotein sulfotransferase 2 caption image width HGNCid 12021 Symbol TPST2 AltSymbols EntrezGene 8459 OMIM 603126 RefSeq NM 003595 UniProt O60704 PDB ECnumber 2.8.2.20 Chromosome 22 Arm q Band 12.1 LocusSupplementaryData Also see Sulfotransferase References reflist External links MeshName tyrosylprotein sulfotransferase transferase stub Sulfur containing group transferases ... more details
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