Unreferenced stub date December 2009 Orphan date December 2009 Allograft diseases are those in which cancerous cells are spread between individuals of the same species by physical contact. To date only two such diseases have been discovered, these are Devil facial tumour disease found in the Tasmanian Devil and Canine transmissible venereal tumor canine transmissible venereal tumour which infects dogs. See also Alloimmunity DEFAULTSORT Allograft Diseases Category Types of animal cancers Veterinary med stub ... more details
Infobox disease Name PAGENAME Image Chronic allograft nephropathy intermed mag.jpg Width 250 Caption Micrograph of chronic allograft nephropathy. PAS stain . DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Chronic allograft nephropathy , abbreviated CAN and also known as sclerosing chronic allograft nephropathy , is the leading cause of kidney transplant failure ref name pmid10469349 Cite journal last1 Paul first1 LC. title Chronic allograft nephropathy An update. journal Kidney Int volume 56 issue 3 pages 783 93 month Sep year 1999 doi 10.1046 j.1523 1755.1999.00611.x PMID 10469349 ref and happens month to years after the transplant. Symptoms CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria . ref name pmid15954891 Cite journal last1 Joosten first1 SA. last2 Sijpkens first2 YW. last3 van Kooten first3 C. last4 Paul first4 LC. title Chronic renal allograft rejection pathophysiologic considerations. journal Kidney Int volume 68 issue 1 pages 1 13 month Jul year 2005 doi 10.1111 j.1523 1755.2005.00376.x PMID 15954891 ref Diagnosis CAN is diagnosed by examination of tissue, e.g. a kidney biopsy . Pathology The histopathology is characterized by interstitial fibrosis , renal tubule tubular atrophy , fibrotic tunica intima intimal thickening of arteries and glomerulosclerosis . ref name pmid15954891 Cite journal last1 Joosten first1 SA. last2 Sijpkens first2 YW. last3 van Kooten first3 C. last4 Paul first4 LC. title Chronic renal allograft rejection pathophysiologic considerations. journal Kidney Int volume 68 issue 1 pages 1 13 month Jul year 2005 doi 10.1111 j.1523 1755.2005.00376.x PMID 15954891 url http www.nature.com ki journal v68 n1 full 4496060a.html ref ref name pmid16534463 Cite journal last1 Nankivell first1 BJ. last2 Chapman first2 JR. title Chronic allograft nephropathy current concepts and future directions. journal Transplantation volume 81 issue 5 pages ... more details
Demineralized freeze dried bone allograft , referred to as DFDBA , is a bone graft material known for its de novo bone formation properties. ref Bowers, GM, et al. Histologic evaluation of new attachment apparatus formation in humans . J Perio 1989 60 683 693 ref It is used extensively in bone grafting of alveolar bone in oral surgery oral and periodontology periodontal surgery. References Reflist Category Dentistry definitions Category Skeletal system ... more details
Demineralized bone matrix DBM is allograft bone that has had the inorganic mineral removed, leaving behind the organic collagen matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins . ref Urist, Marshall R. 1965 . Bone formation by autoinduction . Science 12 150 698 893 899. doi 10.1126 science.150.3698.893. PMID 5319761. ref These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts conversely the mechanical properties are significantly diminished. Current clinical options The success of a bone graft is determined by its ability to recruit host cells to the site of the graft and modulate their conversion into bone forming cells such as osteoblasts , to repair the defect. This will depend on the osteoconductive , osteoinductive and osteogenic capabilities of the graft. Currently, autograft bone harvested from the iliac crest is considered the gold standard due to its superior osteogenic properties. However, associated donor site morbidity , an increased surgery and recovery time, and a limited supply of donor bone are limiting its use ref Graham, S.M., et al., Biological therapy of bone defects the immunology of bone allo transplantation. Expert Opinion on Biological Therapy, 2010. 10 6 p. 885 901. ref . Allograft bone is logical alternative to autograft. However, it must be rigorously processed and terminally sterilized prior to implantation to remove the risk of disease transmission or an immunological response. This processing removes the osteogenic and osteoinductive properties of the graft, leaving only an osteoconductive scaffold . These scaffolds are available .... DBM has superior biological properties to undemineralised allograft bone ref Glowacki, J., S. Zhou ... more details
Orphan date April 2010 Osteopromotive describes a material that promotes the de novo formation of bone . Osteoconductivity describes the property of graft material in which it serves as a scaffold for new bone growth but does not induce bone growth de novo . This means that osteoconductive materials will only contribute to new bone growth in an area where there is already vital bone. Osteoinductivity describes the property of graft material in which it induces de novo bone growth with biomimetic substances, such as bone morphogenetic protein s. Such materials will contribute to new bone growth in an area where there is no vital bone, such as when implanted into muscle tissue. ref name Boyan Boyan, BD, et al. u Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo u . J Perio 2000 71 1278 1286 ref In contrast, osteopromotive substances will not contribute to de novo bone growth but serve to enhance the osteoinductivity of osteoinductive materials. An example of this is enamel matrix derivative , which serves to enhance the osteoinductive nature of demineralized freeze dried bone allograft DFDBA . ref name Boyan References Reflist Category Skeletal system Category Growth factors ... more details
Orphan date February 2009 The meniscus anatomy meniscus is the cartilage in the knee which separates the thigh bone femur from the lower leg bone tibia . A meniscus transplant consists of taking out a worn or damaged meniscus and replacing it with a new one from a donor. The meniscus to be transplanted is taken from a cadaver , and, as such, is known as an allograft . Meniscal transplantation is relatively technically simple, since the meniscus is avascular throughout most of its structure. The procedure is still not 100 satisfactory but is being researched. External links http www.nlm.nih.gov medlineplus ency article 007209.htm Procedure description http www.stjohn.org innerpage.aspx?PageID 338 Procedure description treatment stub Category Orthopedic surgery ... more details
orphan date December 2008 PBB geneid 199 Allograft inflammatory factor 1 is a protein that in humans is encoded by the AIF1 gene . ref name pmid8912632 cite journal author Autieri MV title cDNA cloning of human allograft inflammatory factor 1 tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries journal Biochem Biophys Res Commun volume 228 issue 1 pages 29 37 year 1996 month Dec pmid 8912632 pmc doi 10.1006 bbrc.1996.1612 ref ref name entrez cite web title Entrez Gene AIF1 allograft inflammatory factor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 199 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti inflammatory response to vessel wall trauma. The gene expresses three transcripts. ref name entrez References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Deininger MH, Meyermann R, Schluesener HJ title The allograft inflammatory factor 1 family of proteins journal FEBS Lett. volume 514 issue 2 3 pages 115 21 year 2002 pmid 11943136 doi 10.1016 S0014 5793 02 02430 4 cite journal author Jia J, Zhao YF, Zhao JH title Potential roles of allograft inflammatory factor 1 in the pathogenesis of hemangiomas journal Med. Hypotheses volume 68 issue 2 pages 288 90 year 2007 pmid 17010532 doi 10.1016 j.mehy.2006.07.029 cite journal author Utans U, Arceci RJ, Yamashita Y, Russell ME title Cloning and characterization of allograft inflammatory factor 1 a novel macrophage ... WC, McManus BM, et al. title Allograft inflammatory factory 1. A cytokine responsive macrophage molecule ... R, Schluesener HJ title The allograft inflammatory factor 1 in Creutzfeldt Jakob disease brains ... more details
Multiple issues expert subject November 2008 orphan February 2009 context July 2008 Iba1 ionized calcium binding adaptor molecule 1 is a 17 kDa EF hand protein that is specifically expressed in macrophage s microglia and is upregulated during the activation of these cells. ref cite web work IHC World title Iba1 Antibody Staining Protocol for Immunohistochemistry url http www.ihcworld.com protocols antibody protocols iba1 wako.htm date 2008 04 12 accessdate 2008 07 20 ref The protein is the gene product of the Aif1 gene allograft inflammatory factor 1 which is located within a segment of the major histocompatibility complex class III region. It has been shown that this gene is highly expressed in testis and spleen, but weakly expressed in brain, lung, and kidney. Among brain cells, the Iba1 gene was specifically expressed in microglia. Upon activation of microglia due to inflammation, expression of Iba1 is upregulated allowing the discrimination between surveiling and activated microglia. References reflist Category Proteins protein stub ... more details
Direct and indirect alloantigen recognition are two mechanisms by which T cells may recognize alloantigen s and lead to transplant rejection after an organ transplant . Direct alloantigen recognition Donor tissue macrophages migrate to lymph node s, stimulate a measurable percentage of recipient T cells . The host T cells in the lymph node recognize either the allograft HLA or an associated bound peptide . In this case, alloreactive T cells are stimulated by donor APCs which express both the allogeneic MHC and costimulatory activity . Indirect alloantigen recognition Host organ recipient macrophage s process proteins from the transplanted graft, and trigger a T cell response. Presentation may occur via MHC class I or MHC class II , although class II is usually involved. The main difference between indirect and direct alloantigen recognition stems from the origin of the macrophages type of APC . In direct alloantigen recognition, the involved macrophages are donor derived. In indirect alloantigen recognition, the macrophages APCs involved are recipient. med stub Category Immune system Category T cells ... more details
response against an allograft or xenograft, the process is termed Transplant rejection rejection ... s bone allograft ligament or tendon allograft Bone and tissue allografts have many uses for patients ... from one part of your body for transplantation to another part. Using an allograft eliminates the need ... . See also Allograft diseases Medical grafting External links http www.aatb.org files safetyoftissuetransplants.pdf ... more details
LDA may refer to In aviation Localizer Type Directional Aid Landing distance available, see Runway Declared distances In law Legal drinking age Legal document assistant In medicine Left displaced abomasum Living donor allograft Low dose allergens, a variant of enzyme potentiated desensitization In chemistry , science , technology and mathematics Laser Doppler velocimetry Laser Doppler anemometry Latent Dirichlet allocation , a type of topic model Linear diode array Linear discriminant analysis , a type of statistical analysis Lithium diisopropylamide , a useful strong base in chemistry LoaD Accumulator, an opcode from the MOS Technology 6502 instruction set Local delivery agent, a synonym for mail delivery agent Local density approximation , in quantum mechanical density functional theory Low density amorphous ice Other meanings Lahore Development Authority Late Discovery Adoptees, people discovering adoptee status later in life Les Deux Alpes , a ski resort in France. Liga Deportiva Alajuelense , a Costa Rican football club London Democratic Association London Development Agency Lyme Disease Association Learning Disabilities Association disambig de LDA fa LDA fr LDA it LDA ja LDA ... more details
Lieutenant colonel United States Lieutenant Colonel Robert A. Bob Bowden b. in Irving, Texas is currently an Professor assistant professor in the Chemistry department at the United States Military Academy . Bowden received his Bachelor of Arts B.A. and Doctor of Philosophy Ph.D. in Veterinary medicine veterinary pathobiology immunology from Texas A&M University . He is a published researcher, with articles appearing in AJP Cell Physiology and Infection and Immunity . His most recent work is Long term Aciclovir acyclovir for prevention of varicella zoster virus disease after Allograft allogeneic Hematopoietic stem cell transplantation hematopoietic cell transplantation a randomized double blind double blind placebo controlled study , which was published in the March 2007 issue of Blood journal Blood . External links http www.dean.usma.edu departments Chem FacultyAndStaff Bowden BowdenR.htm LTC Bowden s page at the USMA Persondata NAME Bowden, Bob ALTERNATIVE NAMES SHORT DESCRIPTION United States Army officer DATE OF BIRTH PLACE OF BIRTH Irving, Texas DATE OF DEATH PLACE OF DEATH DEFAULTSORT Bowden, Robert A. Category Year of birth missing living people Category Living people Category People from Irving, Texas Category Texas A&M University alumni Category United States Army officers Category United States Military Academy faculty US military bio stub ... more details
For the word Can disambiguation Wiktionary CAN TOCright CAN may refer to Organizations Andean Community of Nations , a South American trade bloc with Bolivia, Colombia, Ecuador and Peru Campus Antiwar Network , an American network of students opposing the occupation of Iraq Chechnya Advocacy Network , an American non government organization for Chechnya advocacy Christian Association of Nigeria , an umbrella organization containing numerous Christian denominations in Nigeria Climate Action Network , an international non governmental network to limit human induced climate change Corporate Angel Network , an American non profit organization that arranges free air travel for cancer patients Cricket Association of Nepal , governing body of Nepali cricket Cult Awareness Network , an American organization operated by the Church of Scientology Cure Autism Now , a former American organization for autism advocacy Cycling Advocates Network , a New Zealand cycling advocacy group Science and medicine CAN gene , a human gene Calcium ammonium nitrate , a fertilizer Ceric ammonium nitrate , an inorganic compound Chronic allograft nephropathy , the leading cause of kidney transplant failure Computing Campus area network or corporate area network, a computer network in a limited geographical area Cancel character , a precision control character in the C0 control code set Content addressable network , type of P2P network Controller area network , a type of microcontroller bus Other Canada ISO country code , a country in North America Coupe d Afrique des Nations CAN or Africa Cup of Nations , an association football competition in Africa Guangzhou Baiyun International Airport IATA airport code , the main airport in Guangzhou, Guangdong, China disambiguation ca CAN cs CAN da CAN de CAN es CAN eo CAN fr CAN ko CAN it CAN lt CAN nl CAN ja CAN pl CAN ujednoznacznienie pt CAN ro CAN ru Can simple Can sv CAN ... more details
distinguish photophoresis Interventions infobox Name PAGENAME Image Caption ICD10 ICD9unlinked ICD9proc 99.88 MeshID D017893 OPS301 OtherCodes In medicine , photopheresis or extracorporeal photopheresis is a form of apheresis and photodynamic therapy in which blood is treated with photoactivable drugs which are then activated with ultraviolet light . Photopheresis is currently standard therapy approved by the Food and Drug Administration United States U.S. Food and Drug Administration FDA for cutaneous T cell lymphoma . In this procedure, buffy coat White blood cell WBC platelet s is separated from whole blood, chemically treated with 8 methoxypsoralen instilled into collection bag or given per os in advance , exposed to ultraviolet light, and returned to the patient. 8 Methoxypsoralen irreversibly binds covalently to both strands of the DNA of nucleated cells following photoactivation. The photochemically damaged T cell s returned to the patient appear to induce cytotoxic effects on T cell formation. The mechanism of such antitumor action has not been elucidated. Minimal observed adverse effect side effect s for patients receiving photopheresis include hypotension and Syncope medicine syncope resulting from volume shifts during leukapheresis phase of treatment. Photopheresis is also used as an experimental treatment in patients with cardiac, pulmonary and renal allograft rejection, graft versus host disease , autoimmune diseases , nephrogenic systemic fibrosis and ulcerative colitis . See also Blood irradiation therapy External links http www.apheresis.org American Society for Apheresis http www.cancer.gov Templates db alpha.aspx?CdrID 403135 Extracorporeal photopheresis entry in the public domain NCI Dictionary of Cancer Terms http www.emedicine.com derm topic566.htm Extracorporeal photopheresis definition at eMedicine.com http cutaneouslymphoma.stanford.edu community photopheresis.html Extracorporeal photopheresis discussion at Stanford School of Medicine Extraco ... more details
File Lateral window sinus lift.jpg thumb 1 Edentulous area of two missing teeth is being prepared for future placement of dental implant s with a lateral window sinus lift incisions into the gingiva soft tissue are shown here. br 2 The soft tissue is flapped back to expose the underlying lateral wall of the left maxillary sinus . br 3 The bone has been removed with a piezoelectric instrument, exposing the underlying Schneiderian membrane , which is the lining of the maxillary sinus cavity. br 4 Through careful instrumentation, the membrane is carefully peeled from the inner aspect of the sinus cavity. br 5 The membrane has been reflected from the internal aspect of the inferior portion of the sinus cavity one can now visualize the bony floor of the sinus cavity without its lining membrane note the triangular ridge of bone within the sinus, known as an Underwood s septum . br 6 The newly formed space within the bony cavity of the sinus yet inferior to the intact membrane is bone graft grafted with human cadaver allograft bone. The floor of the sinus will now be roughly 10mm or so more superior than it was before, providing enough room to place dental implants into the edentulous site. In anatomy , the Schneiderian membrane is the Mucous membrane membranous lining of the maxillary sinus maxillary sinus cavity . ref Boyne, P James, RA. u Grafting of the maxillary sinus floor with autogenous marrow and bone u . J Oral Maxillofac Surg 1980 38 113 116. ref References reflist Category Head and neck Category Anatomy ... more details
Xenograft Allograft Autograft div Bone grafting is possible because bone tissue, unlike most other ... the osteoinductive effect of demineralized freeze dried bone allograft DFDBA , but will not stimulate ... dried bone allograft in vivo journal J. Periodontol. volume 71 issue 8 pages 1278 86 year 2000 ... thumb 280px A bone allograft. Allografts Allograft bone, like autogenous bone, is derived from humans the difference is that allograft is harvested from an individual other than the one receiving the graft. Allograft bone is taken from cadaver s that have donated their bone so that it can ... bank . There are three types of bone allograft available ref http www.cdc.gov OralHealth Infectioncontrol faq allografts.htm Bone Allografts ref Fresh or fresh frozen bone Freeze dried bone allograft FDBA Demineralized freeze dried bone allograft DFDBA Synthetic variants File Hydrogel HA.jpg thumb ... more details
associated with autograft, other methods such as bone allograft and bone morphogenetic protein s and synthetic ... s own tissue cells that are grafted on an allograft protein scaffold. ref http video.nationalgeographic.com ... more details
is linked from immune tolerance to allografts There are many instance in which an allograft may ... there are also instances in which the strong predicted response to an allograft does not occur.There are two general cases in which an allograft may be accepted.One is when cells or tissue are grafted ... more details
rejection AMR or cardiac allograft vasculopathy CAV . AlloMap has been commercially available ... RC title Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression ... data obtained during the Cardiac Allograft Rejection Gene Expression Observational CARGO Study. From ... more details
R, Volk HD, Milford EL, Gullans SR title Prevention of acute allograft rejection by antibody targeting ... allograft rejection journal Drug News Perspect. volume 18 issue 2 pages 103 8 year 2005 ... and TIRC7 mRNA expression during acute rejection in cardiac allograft recipients journal Transplant ... allograft s ref name pmid17138060 cite journal author Kumamoto Y, Tamura A, Volk HD, Reinke P, L hler ... Utku N, Heinemann T, Milford EL title T cell immune response cDNA 7 in allograft rejection and inflammation ... more details
See also Biomaterial Biomedical material , Implant medicine and Biologic mesh Biomedical tissue is Tissue biology biological tissue used for organ transplant ation and medical research, particularly cancer research. When it is used for research it is a biological specimen . Such tissues and organs may be referred to as implant tissue, allograft , xenograft , skin graft tissue, human transplant tissue, or implant bone. Tissue is stored in tissue establishments or tissue banks under cryogenic conditions. Fluids such as blood, blood products and urine are stored in fluid banks under similar conditions. Regulation The collection, storage, analysis and transplantation of human tissue involves significant ethical and safety issues, and is heavily regulated. Each country sets its own framework for ensuring the safety of human tissue products. The regulation of human transplantation in the United Kingdom is set out in the Human Tissue Act 2004 and managed by the Human Tissue Authority . ref name HTA remit cite web author Human Tissue Authority authorlink Human Tissue Authority title Remit url http www.hta.gov.uk aboutus remit ref Tissue banks in the United States US are monitored by the Food and Drug Administration FDA . The Code of Federal Regulations sets out the following topics ref name CFR2003 cite web author Food and Drug Administration authorlink Food and Drug Administration title Part 1270 Human Tissue Intended for Transplantation year 2003 work Title 21 Food and Drugs publisher Code of Federal Regulations url http www.access.gpo.gov nara cfr waisidx 03 21cfr1270 03.html ref Donor Screening and Testing the determination of donor suitability for human tissue intended for transplantation. Procedures and Records the written procedures and records that must be kept Inspection of Tissue Establishments the importation of tissues from abroad and the retention, recall, and destruction of human tissue. Notable regulation cases Biomedical Tissue Services, Inc. is at the heart ... more details
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