cytarabine MedlinePlus a682222 legal status Rx only pregnancy US D pregnancy AU D routes of administration ... m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey UHDGCWIWMRVCDJ CCXZUQQUSA N Cytarabine ... cytarabine and mitoxantrone as salvage therapy for refractory non Hodgkin s lymphoma journal Jpn. J ... author Ogbomo H, Michaelis M, Klassert D, Doerr HW, Cinatl J title Resistance to cytarabine induces ... is used to kill cancer cells. Cytarabine is the first of a series of cancer drugs that altered ... ref History Cytarabine was first synthesized in 1959 by Richard Walwick, Walden Roberts, and Charles ... drug antiviral , cytarabine functions by inhibiting deoxycytidine use. ref name isbn0 ... pages 963 isbn 0 683 30737 1 oclc doi accessdate ref Cytarabine is rapidly deaminated in the body .... Clinical uses Cytarabine is mainly used in the treatment of acute myeloid leukaemia , acute lymphocytic ... V, Jourdan E, et al. title Adding lomustine to idarubicin and cytarabine for induction chemotherapy ... chemotherapy. Cytarabine also possesses Antiviral drug antiviral activity, and it has been used for the treatment of generalised herpesvirus infection. However, cytarabine is not very selective in this setting ... for the chemotherapy of hematologic cancers. Cytarabine is also used in the study of the nervous system ... impact on neuron s. Side effects One of the unique toxicities of cytarabine is cerebellar toxicity .... ref cite journal author Chhikara BS, Parang K title Development of cytarabine prodrugs and delivery ... a682222.html MedlinePlus page on cytarabine http www.aegis.com factshts network access drugs cyta.html ADAP drugs page on cytarabine http www.bccancer.bc.ca HPI DrugDatabase DrugIndexPro Cytarabine.htm BC Cancer network page on cytarabine http chembank.med.harvard.edu compounds display.html?compound ... of cytarabine. Chemotherapeutic agents DNA antivirals Category Antineoplastic antimetabolites Category Nucleosides Category Pyrimidones de Cytarabin fr Cytarabine ja pl Arabinozyd cytozyny ... more details
AraC may refer to The araC gene and araC protein, components of the L arabinose operon in the genome of the bacterium Escherichia coli Cytarabine , a chemotherapy chemotherapeutic agent commonly used in the treatment of leukemia s and lymphoma s disambig ... more details
Arac may refer to Ara Cytarabine or Ara C Short pages monitor This long comment was added to the page to prevent it from being listed on Special Shortpages. It and the accompanying monitoring template were generated via Template Long comment. Please do not remove the monitor template without removing the comment as well. disambig ... more details
The molecular formula C sub 9 sub H sub 13 sub N sub 3 sub O sub 5 sub may refer to Cytarabine Cytidine MolFormDisambig C sub 9 sub H sub 13 sub N sub 3 sub O sub 5 sub fr C9H13N3O5 sr C9H13N3O5 ... more details
chembox verifiedrevid 384065455 ImageFile Ara CTP.svg ImageSize IUPACName OtherNames Ara CTP, Cytarabine triphosphate, br Cytosine arabinoside triphosphate Reference ref name pubchem http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 25774 Ara CTP Compound Summary , PubChem . ref Section1 Chembox Identifiers CASNo 13191 15 6 PubChem 25774 SMILES C1 CN C O N C1N C2C C C O2 COP O O OP O O OP O O O O O MeSHName Arabinofuranosylcytosine triphosphate Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 14 sub P sub 3 sub MolarMass 483.156323 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the protein biosynthesis synthesis of DNA . It is the biologically active form of cytarabine . ref name pubchem References reflist Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Pyrimidones organic compound stub fa zh ... more details
wiktionary beam Beam may refer to Beam structure , a construction element Beam nautical , the most extreme width or breadth of a nautical vessel, or a point alongside the ship at the mid point of its length A narrow, propagating stream of particles or energy Bessel beam Gaussian beam Light beam Laser beam Particle beam Charged particle beam Cathode ray , or electron beam Beam Inc. , a NYSE listed spirits company that produces Jim Beam , a popular brand of Bourbon whiskey , and a variety of other brands Beam music , a connection line in musical notation Balance beam , a piece of gymnastics equipment BEAM robotics , an automatically moving machine based on analog electronics Beam search , a search algorithm Beam Software , a computer game developer BEAM.TV , a global distribution network Blaster Beam , a musical instrument BEAM, an aggressive chemotherapy regimen involving the use of Carmustine BCNU Carmustine , Etoposide , Cytarabine Ara C Cytarabine , and Melphalan BEAM, neuroimaging brain electrical activity mapping BEAM, the virtual machine at the core of the Erlang programming language Erlang programming language Beam, operate the Transporter Star Trek Transporter in the fictional Star Trek series See also Beam theory , a means of calculating the load carrying and deflection characteristics of beams Battle of the Beams , radio countermeasures used against navigational system used by the Luftwaffe during WWII The Beam disambiguation disambiguation ang B am da Trave de Beam ja pt Trave simple Beam tl Beam th ... more details
This is a list of specific Wiktionary pharmacological agent pharmacologic agents that are known to be of use in the treatment of cancer , otherwise known as Wiktionary chemotherapeutic agent chemotherapeutic agents . This list is organized by type of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is listed once at present , though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. Expand list date August 2008 Alkylating agents Cyclophosphamide Mechlorethamine Chlorambucil Melphalan Anthracyclines article on anthracycline s Daunorubicin Doxorubicin Epirubicin Idarubicin Mitoxantrone Valrubicin Cytoskeletal disruptors Taxanes Paclitaxel Docetaxel Epothilones article on epothilone s Histone Deacetylase Inhibitors Vorinostat Romidepsin Inhibitors of Topoisomerase II Etoposide Teniposide Tafluposide Kinase Inhibitors Bortezomib Erlotinib Gefitinib Imatinib Vismodegib Monoclonal Antibodies Bevacizumab Cetuximab Ipilimumab Ofatumumab Ocrelizumab Panitumab Rituximab Vemurafenib Nucleotide analogs and precursor analogs Azacitidine Azathioprine Capecitabine Cytarabine Doxifluridine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Tioguanine formerly Thioguanine Peptide antibiotics Bleomycin Actinomycin Platinum based agents Carboplatin Cisplatin Oxaliplatin Retinoids Tretinoin Alitretinoin Bexarotene Vinca alkaloids and derivatives Vinblastine Vincristine Vindesine Vinorelbine Full alphabetical listing Actinomycin All trans retinoic acid Azacitidine Azathioprine Bleomycin Bortezomib Carboplatin Capecitabine Cisplatin Chlorambucil Cyclophosphamide Cytarabine Daunorubicin Docetaxel Doxifluridine Doxorubicin Epirubicin Epothilone Etoposide Fluorouracil Gemcitabine Hydroxyurea Idarubicin Imatinib Mechlorethamine Mercaptopurine Methotrexate Mitoxantrone Oxaliplatin Paclitaxel Pemetrexed Teniposide Tioguanine Valrubicin Vinblastine Vincristine Vindesin ... more details
specificity of chemotherapy drugs ref name chabner ref name skeel . Cytarabine , a DNA synthesis inhibitor ... . Chemotherapy dosing schedules have been optimized based on the fact that cytarabine is only expected ... with this, leukemia patients respond better to cytarabine treatments given every 12 hours rather ... cotter . In fact, a trace through the literature on the S phase specificity of cytarabine leads to studies that simply assume S phase specificity based on cytarabine s reported site of biochemical ... more details
Infobox Company company name Vion Pharmaceuticals, Inc. company logo Image Vion Pharmaceuticals Logo.gif company type Public company Public http finance.yahoo.com q?s VIONQ.OB OTC BB VIONQ.OB foundation 1992 defunct 2009 location New Haven, Connecticut , United States key people num employees industry Pharmaceuticals products revenue homepage http www.vionpharm.com www.vionpharm.com Vion Pharmaceuticals, Inc. is a New Haven , Connecticut based pharmaceutical company founded in March 1992 to commercialize several discoveries made in the biomedical laboratories at Yale University . Clinical Development Two anticancer agents, Onrigin laromustine , formerly Cloretazine VNP40101M , and Triapine, are in human clinical trials . Onrigin laromustine , a novel alkylating agent, is being evaluated in a Phase 2 trial in elderly de novo poor risk AML. In addition, four trials of Onrigin laromustine are underway in i elderly AML and myelodysplastic syndrome MDS in combination with cytarabine ii AML and MDS in combination with standard remission induction therapy iii brain tumors in combination with temozolomide and iv advanced hematologic malignancies in combination with hematopoietic cell transplantation. Triapine, a ribonucleotide reductase inhibitor, is being evaluated in clinical trials sponsored by the National Cancer Institute . External links http www.vionpharm.com Official web site Pharmaceutical companies of the United States Category Companies based in New Haven County, Connecticut Category Pharmaceutical companies of the United States med company stub ... more details
Drugbox Watchedfields changed verifiedrevid 443275125 IUPAC name 5 amino 2 2 dimethylamino ethyl 1 H benzo de isoquinoline 1,3 2 H dione image Amonafide.svg Clinical data tradename pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Pharmacokinetic data bioavailability protein bound metabolism elimination half life excretion Identifiers CAS number 69408 81 7 ATC prefix none ATC suffix PubChem 50515 DrugBank Ref drugbankcite correct drugbank DrugBank ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 45804 UNII Ref fdacite correct FDA UNII 1Q8D39N37L ChEMBL Ref ebicite correct EBI ChEMBL 428676 Chemical data C 16 H 17 N 3 O 3 molecular weight 283.325 g mol smiles O C2c1c3c ccc1 cc cc3C O N2CCN C C N StdInChI Ref stdinchicite correct chemspider StdInChI 1S C16H17N3O2 c1 18 2 6 7 19 15 20 12 5 3 4 10 8 11 17 9 13 14 10 12 16 19 21 h3 5,8 9H,6 7,17H2,1 2H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey UPALIKSFLSVKIS UHFFFAOYSA N Amonafide originally AS1413 International Nonproprietary Name INN , trade name Quinamed is a drug that is being studied in the treatment of cancer . It belongs to the families of drugs called topoisomerase inhibitor s and DNA intercalator s. It is being developed as an anti cancer therapy by Antisoma . ref http www.genengnews.com news bnitem.aspx?name 78979622 ref As of 2008 , it is in clinical trial Phase III Phase III clinical trial s. eg In March 2010 it is Phase III trial against secondary acute myeloid leukaemia AML . ref http clinicaltrials.gov ct2 show NCT00715637 Phase III Randomized Study of Amonafide AS1413 and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia AML the ACCEDE Study ref References reflist External l ... more details
started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine . ref ClinicalTrialsGov NCT00651261 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly ... more details
11 14 Cytarabine or Ara C Cytosar is an antimetabolite 70mg IT Day 7 Mesna Uromitexan is a compound ... of methotrexate. Cytarabine 3000mg m2 IV over 2 hours Q12H X 4 doses Days 2 and 3 Side effects ... more details
in combination with Idarubicin and Cytarabine . ref cite web url http www.mdsbeacon.com news 2012 01 11 zolinza vorinostat idarubicin cytarabine combination yields high response rates for mds patients ash 2011 title Zolinza, Idarubicin, Cytarabine Combination Yields High Response Rates In MDS ... more details
to live, with half treated with lintuzumab and a low dose of the chemotheraputic agent cytarabine , while the other half were given cytarabine in combination with a placebo . No patients were harmed ... more details
Unreferenced stub auto yes date December 2009 Nucleoside analogues are a range of antiviral products used to prevent virus viral replication in infected cells. The most commonly used is Acyclovir , although its inclusion in this category is uncertain, as it contains only a partial nucleoside structure, as the pentose sugar ring is replaced by an open chain structure. Function These agents can be used against hepatitis B virus , hepatitis C virus , herpes simplex , and HIV . Once they are Phosphorylation phosphorylated , they work as antimetabolite s by being similar enough to nucleotide s to be incorporated into growing DNA strands but they act as chain terminators and stop viral DNA Polymerase. They are not specific to viral DNA and also affect mitochondrial DNA. Because of this they have side effects such as bone marrow suppression. There is a large family of reverse transcriptase inhibitor Nucleoside analog reverse transcriptase inhibitors NARTIs or NRTIs nucleoside analogue reverse transcriptase inhibitor s, because DNA production by reverse transcriptase is very different from normal human DNA replication , so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs and polymerase inhibitors for other viruses e.g., hepatitis B . Less selective nucleoside analogues are used as chemotherapy agents to treat cancer . Resistance Resistance can develop quickly with as little as one mutation. Citation needed reason an example from the literature would be nice date March 2009 Mutations occur in the enzymes that phosphorylate the drug to activate it. Examples Nucleoside analogue drugs include deoxyadenosine analogues Didanosine ddI HIV Vidarabine chemotherapy deoxycytidine analogues Cytarabine chemotherapy Emtricitabine FTC HIV Lamivudine 3TC HIV, hepatitis B Zalcitabine ddC HIV deoxyguanosine analogues Abacavir HIV Entecavir hepatitis B deoxy thymidine analogues Stav ... more details
Infobox disease Name Chemotherapy induced acral erythema Image Hand foot Syndrome.jpg Caption Pictures of hands on capecitabine Picture of hands on capecitabine exhibiting signs of chemotherapy induced acral erythema DiseasesDB 34044 ICD10 ICD10 Y 43 1 y 40 ICD10 Y 43 3 y 40 ICD9 ICD9 693.0 , ICD9 E933.1 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Chemotherapy induced acral erythema also known as palmar plantar erythrodysesthesia or hand foot syndrome is reddening, swelling, numbness and desquamation on palms and soles that can occur after chemotherapy in patients with cancer. Hand foot syndrome is also seen at Sickle cell disease . These skin changes usually are well demarcated. Acral erythema typically disappears within a few weeks after discontinuation of the offending drug. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. rp 132 ref ref Palmar plantar rash with cytarabine therapy. Rosenbeck L, Kiel PJ. N Engl J Med. 2011 Jan 20 364 3 e5. ref Synonyms Synonyms for acral erythema AE include hand foot syndrome , palmar plantar erythrodysesthesia , peculiar AE, chemotherapy induced AE, toxic erythema of the palms and soles, palmar plantar erythema , and Burgdorf s reaction . History Hand foot syndrome was first reported in association with chemotherapy by Zuehlke in 1974. ref Erythematous eruption of the palms and soles associated with mitotane therapy. Zuehlke RL. Dermatologica. 1974 148 2 90 2. ref Pathogenesis The cause of PPE is unknown. Existing theories are based on the fact that only the hands and feet are involved and posit the role of temperature differences, vascular anatomy, differences in the types of cells rapidly dividing epidermal cells and eccrine glands . Offending drugs The offending drug leading to acral erythema as an adverse drug reaction usually is a cytotoxic drug, very commonly fluorouracil , capecitabine , cytarabine ... more details
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