A decamer is an oligomer composed of 10 number ten sub unit s. See also wiktionary decamer Decameron disambiguation deca , a prefix mer , an affix chemistry stub Category Oligomers ... more details
Dicdef Multiple issues prose May 2011 unreferenced October 2010 notability May 2011 Other uses Mer disambiguation Mer wiktionarypar mer mer and mer from Greek meros , part are affix es used in the following words. Chemistry or biochemistry Monomer Dimer Trimer Tetramer Pentamer Hexamer Heptamer Octamer Nonamer Decamer Dodecamer Oligomer Polymer Enantiomer Heteromer Homeomer Isomer Biology Merosity , a characteristic regarding the flower petals number in plants Metamery , a characteristic of segmented animals DEFAULTSORT mer Category suffixes Category prefixes de mer vocab stub chem stub ... more details
About the SI prefix Deca disambiguation Deca Wiktionarypar deca Deca or deka ref name SP811 http physics.nist.gov Pubs SP811 sp811.html Guide for the Use of the International System of Units SI , 1995, NIST Special Publication 811 ref symbol da is a SI prefix prefix in the metric system , also a numerical prefix , denoting a factor of ten. The term is derived from the Greek language Greek meaning ten . Its symbol is the only SI prefix that uses more than one character. The prefix was a part of the original metric system in 1795. It is not in very common usage, although the decapascal is occasionally used by audiologists. The decanewton is also encountered occasionally, probably because it is an SI approximation of the kilogram force . Its use is more common in Central Europe in German, Czech, Slovak and Hungarian, deca is common and always means decagram . Before the symbol was standardized as da with the introduction of the International System of Units in 1960, various other symbols were more common, such as dk , D , and Da . 1 decametre 10 metre s 1 decalitre 10 litres 1 decare 10 are s SI prefixes References references See also Decamer , a thing composed of ten sub units External links http www.bipm.org BIPM website Categories Category SI prefixes Interwiki be bg br Deka ca Deca cs Deka et Deka es Deca fa gl Deca ko hy hi id Deka it Deca ka ... lt Deka nl Deca prefix ja no Deka nn Deka km nds Deka pl Deka pt Deca ksh Deka ru sl Deka sr vi ca ... more details
Infobox protein family Symbol Cyanate lyase Name Cyanate lyase image PDB 1dwk EBI.jpg width caption structure of cyanase with the di anion oxalate bound at the enzyme active site Pfam PF02560 Pfam clan InterPro IPR003712 SMART PROSITE MEROPS SCOP 1dw9 TCDB OPM family OPM protein CAZy CDD In molecular biology, cyanate hydratase EC number 4.2.1.104 is an enzyme which catalyses the hydrolysis of cyanate . It is also known as cyanate lyase or cyanase. Some bacteria can overcome the toxic toxicity of environmental cyanate by hydrolysis of cyanate by this enzyme. ref name pmid3049588 cite journal author Sung YC, Fuchs JA title Characterization of the cyn operon in Escherichia coli K12 journal J. Biol. Chem. volume 263 issue 29 pages 14769 75 year 1988 month October pmid 3049588 doi url ref Cyanate hydratase is found in bacterium bacteria and plants and Catalysis catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide . The cyanate hydratase monomer is composed of two protein domain domains . The N terminal domain shows secondary structure structural similarity to the DNA binding alpha helix bundle motif. The C terminal domain has an open protein folding fold with no structural homology to other protein s. The protein dimer dimer structure reveals the C terminal protein domains domains to be intertwined, and a decamer is formed by a pentamer of these protein dimer dimers . The active site of the enzyme is located between dimers and is composed of residues from four adjacent protein subunit subunits of the homodecamer. ref name pmid10801492 cite journal author Walsh MA, Otwinowski Z, Perrakis A, Anderson PM, Joachimiak A title Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site journal Structure volume 8 issue 5 pages 505 14 year 2000 month May pmid 10801492 doi 10.1016 S0969 2126 00 00134 9 url ref References reflist InterPro content IPR003712 Category P ... more details
otheruses . For the Marcus Gunn pupil defect aka relative afferent pupillary defect, see Marcus Gunn pupil Unreferenced date October 2007 RAPD pronounced rapid stands for random amplification of polymorphic DNA . It is a type of PCR reaction, but the segments of DNA that are amplified are random. The scientist performing RAPD creates several arbitrary, short primers 8 12 nucleotides , then proceeds with the PCR using a large template of genomic DNA, hoping that fragments will amplify. By resolving the resulting patterns, a semi unique profile can be gleaned from a RAPD reaction. No knowledge of the DNA sequence for the targeted gene is required, as the primers will bind somewhere in the sequence, but it is not certain exactly where. This makes the method popular for comparing the DNA of biological systems that have not had the attention of the scientific community, or in a system in which relatively few DNA sequences are compared it is not suitable for forming a DNA databank . Because it relies on a large, intact DNA template sequence, it has some limitations in the use of degraded DNA samples. Its resolving power is much lower than targeted, species specific DNA comparison methods, such as short tandem repeats . In recent years, RAPD has been used to characterize, and trace, the phylogeny of diverse plant and animal species. Introduction RAPD markers are decamer 10 nucleotide length DNA fragments from PCR amplification of random segments of genomic DNA with single primer of arbitrary nucleotide sequence and which are able to differentiate between genetically distinct individuals, although not necessarily in a reproducible way. It is used to analyse the genetic diversity of an individual by using random primers. Due to problems in experiment reproducibility, many scientific journals do not accept experiments merely based on RAPDs anymore. How it works Unlike traditional PCR analysis, RAPD does not require any specific knowledge of the DNA sequence of the target orga ... more details
PBB geneid 9445 Integral membrane protein 2B is a protein that in humans is encoded by the ITM2B gene . ref name pmid9795190 cite journal author Pittois K, Deleersnijder W, Merregaert J title cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B journal Gene volume 217 issue 1 2 pages 141 9 year 1998 month Nov pmid 9795190 pmc doi 10.1016 S0378 1119 98 00354 0 ref ref name entrez cite web title Entrez Gene ITM2B integral membrane protein 2B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9445 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text ITM2B or BRI2 is a gene located on chromosom 13. The gene is connected to Familial Danish Disease FDD and Familial British Disease FBD causing amyloid and pre filbrillar effects similar to those seen in Alzheimers Disease AD . References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Rostagno A, Tomidokoro Y, Lashley T, et al. title Chromosome 13 dementias. journal Cell. Mol. Life Sci. volume 62 issue 16 pages 1814 25 year 2005 pmid 15968464 doi 10.1007 s00018 005 5092 5 cite journal author Ernst B, Dalby MA, Dalby A title Luria testing in demented patients. journal Acta Neurol. Scand. volume 46 issue pages Suppl 43 97 8 year 1970 pmid 5466275 doi 10.1111 j.1600 0447.1970.tb01106.x cite journal author Vidal R, Frangione B, Rostagno A, et al. title A stop codon mutation in the BRI gene associated with familial British dementia. journal Nature volume 399 issue 6738 pages 776 81 year 1999 pmid 10391242 doi 10.1038 21637 cite journal author Vidal R, Revesz T, Rostagno A, et al. title A decamer duplication in the 3 region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue 9 pa ... more details
PBB geneid 6720 Sterol regulatory element binding transcription factor 1 SREBF1 also known as sterol regulatory element binding protein 1 SREBP 1 is a protein that in humans is encoded by the SREBF1 gene . ref name pmid8402897 cite journal author Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS title SREBP 1, a basic helix loop helix leucine zipper protein that controls transcription of the low density lipoprotein receptor gene journal Cell volume 75 issue 1 pages 187 97 year 1993 month November pmid 8402897 pmc doi 10.1016 S0092 8674 05 80095 9 ref ref name pmid7759101 cite journal author Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH title Structure of the human gene encoding sterol regulatory element binding protein 1 SREBF1 and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13 journal Genomics volume 25 issue 3 pages 667 673 year 1995 month June pmid 7759101 pmc doi 10.1016 0888 7543 95 80009 B ref This gene is located within the Smith Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. ref cite web title Entrez Gene SREBF1 sterol regulatory element binding transcription factor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6720 accessdate ref The isoforms are SREBP 1a and 1c ADD 1 . Function Main Sterol regulatory element binding protein The proteins encoded by this gene are transcription factors that bind to a sequence in the Promoter biology promoter of different genes, called sterol regulatory element 1 SRE1 . This element is a decamer flanking the LDL receptor gene and other genes involved in, for instance, sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum . Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and th ... more details
Image Morpheein dice.PNG thumb 400px right Proteins that function as morpheeins are illustrated using a dice analogy where one die can morph to two different shapes, cubic and tetrahedral. The illustrated assemblies apply a rule that the die face with one spot must contact the die face with four spots. To satisfy the rule for each die in an assembly, the cubic die can only form a tetramer and the tetrahedral die can only assemble to a pentamer. This is analogous to two different conformations morpheein forms of a protein subunit each dictating assembly to a different oligomer. All dice in one assembly must be of the same shape before assembly. Thus, for example, the tetramer must come apart, and its component dice must change shape to a pyramid before they can participate in assembly into a pentamer. Morpheein a protein that can form two or more different homo oligomer s morpheein forms , but must come apart and change shape to convert between forms. The alternate shape may reassemble to a different oligomer. The shape of the subunit dictates which oligomer is formed. ref name pmid16023348 cite journal author E.K. Jaffe title Morpheeins a new structural paradigm for allosteric regulation journal Trends Biochem. Sci. volume 30 issue 9 pages 490 497 year 2005 pmid 16023348 url http www.ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&dopt Citation&list uids 16023348 doi 10.1016 j.tibs.2005.07.003 ref ref name pmid12897770 cite journal author S. Breinig, J. Kervinen, L. Stith, A.S. Wasson, R. Fairman, A. Wlodawer, A. Zdanov and E.K. Jaffe title Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase journal Nat. Struct. Biol. volume 10 issue 9 pages 757 763 year 2003 pmid 12897770 url http www.ncbi.nlm.nih.gov entrez query.fcgi?cmd Retrieve&db PubMed&dopt Citation&list uids 12897770 doi 10.1038 nsb963 ref Each oligomer has a finite number of subunits stoichiometry . Morpheeins can interconvert between forms under physiolo ... more details
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