In enzymology, a [phosphorylase] phosphatase () is an enzyme that catalyzes the chemical reaction

[phosphorylase a] + 4 H₂O \rightleftharpoons 2 [phosphorylase b] + 4 phosphate

Thus, the two substrates of this enzyme are phosphorylase a and H₂O, whereas its two products are phosphorylase b and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [phosphorylase a] phosphohydrolase. Other names in common use include PR-enzyme, phosphorylase a phosphatase, glycogen phosphorylase phosphatase, protein phosphatase C, and type 1 protein phosphatase.

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