In enzymology, a 5-amino-6-(5-phosphoribosylamino)uracil reductase () is an enzyme that catalyzes the chemical reaction

5-amino-6-(5-phosphoribitylamino)uracil + NADP⁺ \rightleftharpoons 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H⁺

Thus, the two substrates of this enzyme are 5-amino-6-(5-phosphoribitylamino)uracil and NADP⁺, whereas its 3 products are 5-amino-6-(5-phosphoribosylamino)uracil, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , and .

References

it:5-amino-6-(5-fosforibosilamino)uracil reduttasi ja:5- -6-(5- )