In enzymology, a 6-aminohexanoate-cyclic-dimer hydrolase () is an enzyme that catalyzes the chemical reaction

1,8-diazacyclotetradecane-2,9-dione + H₂O \rightleftharpoons N-(6-aminohexanoyl)-6-aminohexanoate

Thus, the two substrates of this enzyme are 1,8-diazacyclotetradecane-2,9-dione and H₂O, whereas its product is N-(6-aminohexanoyl)-6-aminohexanoate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 1,8-diazacyclotetradecane-2,9-dione lactamhydrolase.

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