7,12-Dimethylbenz(a)anthracene is an immunosuppressor and a powerful organ-specific laboratory carcinogen.^[1] Also known as 7,12-dimethylbenz[ ]anthracene or DMBA, this substance is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator by making necessary mutations. Tumor promotion can be induced with treatments of TPA (12-O-tetradecanoylphorbol-13-acetate) in some models of two-stage carcinogenesis.^[2] This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.

References

de:7,12-Dimethylbenz(a)anthracen ja:7,12- (a)