A43 or A-43 may refer to:

• A43 road (England), a primary road in the English Midlands
• One of the Encyclopaedia of Chess Openings codes for the Benoni Defense in chess
• One of two United States combat aircraft designations:
  • Curtiss-Wright XF-87 Blackhawk
  • Douglas XB-43 Jetmaster
• HLA-A43, an HLA-A serotype

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