Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.^[1]

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

This is a diagonal plot of the protein displaying internal repeats.

      1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE      41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA      81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN     121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL     161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE     201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK     241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS     301 FMSLFIRNGN REILLETPAP 

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.^[2][3]

                           10        20        30        40                 ....*....|....*....|....*....|....*....|....*.. ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277 1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65                  + +   ++ +  +  + + +   +   + +    +  +  ++++  

Cyanase segment having identity with ARMCX6.

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice. ^[4][5][6]

References

Further reading