Diagram of an ectodomain shedding ADAM metalloprotease. ADAM (A Disintegrin And Metalloproteinase)^[1] is a family of peptidase proteins.^[2] It is also known as the adamalysin family or MDC family(metalloproteinase-like, Disintegrin-like, cysteine rich). ADAMs are classified as sheddases because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, activating it.^[3] Therapeutic ADAM inhibitors can potentiate anti-cancer therapy.

It is categorized under .

Family members are:

• ADAM2
• ADAM7
• ADAM8
• ADAM9
• ADAM10
• ADAM11
• ADAM12
• ADAM15
• ADAM17
• ADAM18 (=ADAM27)
• ADAM19
• ADAM20
• ADAM21 (=ADAM31)
• ADAM22
• ADAM23
• ADAM28
• ADAM29
• ADAM30
• ADAM33

See also

• ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) family
• Ectodomain shedding

References

External links

• http://www.healthvalue.net/sheddase.html

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