Ace of Clubs may refer to:

• Ace of Clubs, the Ace playing card
• Ace of Clubs (comics), a DC Comics supervillain
• Ace of Clubs (musical), a 1949 musical by No l Coward
• Ace of Clubs Records, a British record label owned by Decca Records
• The Ace of Clubs, an alias used by British recording artist Luke Vibert
• The Ace of Clubs (film), a 1926 silent Western film