In enzymology, an acetylenedicarboxylate decarboxylase () is an enzyme that catalyzes the chemical reaction

acetylenedicarboxylate + H₂O \rightleftharpoons pyruvate + CO₂

Thus, the two substrates of this enzyme are acetylenedicarboxylate and H₂O, whereas its two products are pyruvate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is acetylenedicarboxylate carboxy-lyase (pyruvate-forming). Other names in common use include acetylenedicarboxylate hydratase, acetylenedicarboxylate hydrase, and acetylenedicarboxylate carboxy-lyase. This enzyme participates in pyruvate metabolism.

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