In enzymology, an aconitate decarboxylase () is an enzyme that catalyzes the chemical reaction

cis-aconitate \rightleftharpoons itaconate + CO₂

Hence, this enzyme has one substrate, cis-aconitate, and two products, itaconate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is cis-aconitate carboxy-lyase (itaconate-forming). Other names in common use include cis-aconitic decarboxylase, CAD, cis-aconitate carboxy-lyase, and cis-aconitate carboxy-lyase. This enzyme participates in c5-branched dibasic acid metabolism.

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