Adenine nucleotide translocator (ANT) also known as the ADP/ATP translocator is a mitochondrial protein.

Function

ANT has long been thought to function asymmetrically as a homodimer of subunits in the inner mitochondrial membrane. The dimer was thought to be a gated pore through which ADP and ATP were exchanged between the mitochondrial matrix and the cytoplasm. The dimer hypothesis was first challenged when the three-dimensional structure of ANT was discovered to be a monomer.^[1] Further work has shown that ANT functions a monomer in detergents^[2] and in mitochondrial membranes.^[3][4]

Types

In humans, there exist three paraologous ANT isoforms:

• SLC25A4 found primarily in heart and skeletal muscle
• primarily expressed in fibroblasts
• SLC25A6 primarily express in liver

See also

• mitochondrial carrier

Footnotes

External links