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The Adenine Pathway in yeast is a seven step pathway converting Phosphoribosyl pyrophosphate (PRPP) to adenine. This product is then either integrated into DNA, RNA, or a ribose diphosphate molecule ADP, the precursor of ATP, an essential intermediate storage molecule for most cellular processes. Mechanism The ADE series of enzymes converts the most precursory molecule, PRPP, into adenine by this seven step process. AIR synthetase is ADE 6, and essentially is what closes the five membered ring to form the purine base. | Molecular precursor | Enzyme | | PRPP | none (original precursor) | | P-ribosylamine | ADE4 | | P-ribosylglycinamide | ADE5 | | P-ribosylformyl glycinamide | ADE8 | | P-ribosylformyl glycinamidine | ADE6 | | P-ribosylamino imidazole (AIR) | ADE7 | | P-ribosylamino imidazolecarboxylate (CAIR) | ADE2 | | P-ribosylsuccino carboxamide aminoimidazole (SAICAR) | ADE1 | | Adenine | <gallery> File:Adenine pathway.jpg|The molecular formulas of the intermediates. click to enlarge. </gallery> <gallery> </gallery> Mutation Deletion or mutation in Ade2 results in the accumulation of a red precursor in the cells. Colonies formed by such cells would therefore be red. References 1.Montelone, Beth A. "Frequently Asked Questions--Yeast Strains." Physics Department at Kansas State University. Web. 24 December 2009. <http://www.phys.ksu.edu/gene/GENEFAQ.html>.
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