Against the Grain may refer to:

Broadcast media

• Against the Grain (TV series), 1993 NBC drama series with Ben Affleck
• Against the Grain (radio program), an interview program on Pacifica Radio station KPFA, Berkeley, hosted by C.S. Soong
• Against the Grain, a regular segment on The Dan Patrick Show

Music

• Against the Grain (Acoustic Alchemy album), 1994 album by the band Acoustic Alchemy
• Against the Grain (Bad Religion album), 1990 album by the band Bad Religion
• Against the Grain (Phoebe Snow album), 1978 album by Phoebe Snow
• Against the Grain (Redgum album), a 2004 Redgum greatest hits album
• Against the Grain (Rory Gallagher album), a 1975 album by Rory Gallagher
• Against the Grain (Snakefinger album), 1983 album by the musician Snakefinger
• Against the Grain (The Veer Union album), 2009 album by The Veer Union
• "Against the Grain", song by country-western singer Garth Brooks on his 1991 album Ropin' the Wind
• "Against the Grain", a song by R&B singer Akon on his 2008 album Freedom

Books

• Against the Grain: Mad Artist Wallace Wood, edited by Bhob Stewart
• Against the Grain, one English title of rebours, Symbolist novel by Joris-Karl Huysmans, also known as Against Nature, the second English title
• Against the Grain: An Autobiography, by Boris Yeltsin
• Against the Grain: How Agriculture Has Hijacked Civilization, by Richard Manning

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