Baby weighed as AGA

There have been numerous studies that have attempted, with varying degrees of success, to show links between birth weight and later-life conditions, including diabetes, obesity, tobacco smoking and intelligence.

Determinants

There are basically two distinct determinants for birth weight:

• The duration of gestation prior to birth, that is, the gestational age at which the child is born

Relation of weight and gestational age.

• The prenatal growth rate, generally measured in relation to what weight is expected for any gestational age.

The incidence of birth weight being outside what is normal is influenced by the parents in numerous ways, including:

• Genetics
• The health of the mother, particularly during the pregnancy
• Environmental factors, including exposure of the mother to secondhand smoke^[2]
• Economic status of the parents gives inconsistent study findings according to a review on 2010, and remains speculative as a determinant.^[3]
• Other factors, like multiple births, where each baby is likely to be outside the AGA, one more so than the other

Abnormalities

• A low birth weight can be caused either by a preterm birth (low gestational age at birth) or of the infant being small for gestational age (slow prenatal growth rate), or a combination of both.
• A very large birth weight is usually caused by the infant having been large for gestational age

Influence on adult life

Studies have been conducted to investigate how a person's birth weight can influence aspects of their future life. This includes theorised links with obesity, diabetes and intelligence.

Obesity

A baby born small or large for gestational age (either of the two extremes) is thought to have an increased risk of obesity in later life.^[4][5][6]

GH therapy at a certain dose induced catch-up of lean body mass (LBM). However percentage body fat decreased in the GH-treated subjects. Bone mineral density SDS measured by DEXA increased significantly in the GH-treated group compared to the untreated subjects, though there is much debate over whether or not SGA (small for gestational age) is significantly adverse to children to warrant inducing catch-up.^[7]

Diabetes

Babies that have a low birth weight are thought to have an increased risk of developing type 2 diabetes in later life.^[8][9][10]

Intelligence

Some studies have shown a direct link between an increased birth weight and an increased intelligence quotient.^[11][12][13]

Epidemiology

Disability-adjusted life year for low birth weight per 100,000 inhabitants in 2002.^[14]

See also

• Barker's hypothesis
• MOMO syndrome
• Low birth weight paradox
• Prenatal nutrition and birth weight

References

External links

• "Intrauterine growth restriction (IUGR)" at Health System, University of Virginia
• "Researchers link low birth weight to lower achievement"
• "Management of Suspected Fetal Macrosomia"
• "Vit D linked to baby birth weight" at BBC News, 25 April 2006
• Born in Bradford - 2006 cohort study into the causes of low birth weight and infant mortality in Bradford, UK
• Intrauterine Growth Restriction Help - IUGR factors and solutions

ar: es:Restricci n del crecimiento intrauterino fr:Retard de croissance intra-ut rin hi: it:Restrizione della crescita intrauterina nl:Geboortegewicht